{"id":1618,"date":"2026-03-26T03:27:07","date_gmt":"2026-03-26T06:27:07","guid":{"rendered":"https:\/\/datamining.dc.uba.ar\/datamining\/?p=1618"},"modified":"2026-04-10T11:43:10","modified_gmt":"2026-04-10T14:43:10","slug":"defensa-de-tesis-alvaro-lopez-malizia-10-04-2026-10-hs","status":"publish","type":"post","link":"https:\/\/datamininguba.com.ar\/datamining\/2026\/03\/26\/defensa-de-tesis-alvaro-lopez-malizia-10-04-2026-10-hs\/","title":{"rendered":"Defensa de Tesis &#8211; \u00c1lvaro L\u00f3pez Malizia \u2013 10\/04\/2026 \u2013 10 hs."},"content":{"rendered":"<p>El Viernes 10\/04 se realiz\u00f3 la Defensa de Tesis de \u00c1lvaro L\u00f3pez Malizia titulada \u201cAnotaci\u00f3n de genomas de helmintos mediante aprendizaje autom\u00e1tico\u201d.\u00a0 Cont\u00f3 con la direcci\u00f3n de la Dra. Laura Kamenetzky y la co-direcci\u00f3n de la Dra. Georgina Silvia Stegmayer. Los jurados fueron el Dr. Marcelo Soria, el Dr. Alejandro Nadra y la Dra. Mar\u00eda Elena Buemi. La defensa puede verse a trav\u00e9s del siguiente link: <a href=\"https:\/\/www.youtube.com\/live\/NTipLTRHD_8\" target=\"_blank\" rel=\"noopener\">https:\/\/www.youtube.com\/live\/NTipLTRHD_8<\/a><\/p>\n<p>Resumen:<\/p>\n<p>A pesar de los avances en secuenciaci\u00f3n, muchos genomas de nematodos carecen de anotaciones funcionales de sus secuencias codificantes, ya que los m\u00e9todos experimentales tradicionales resultan costosos y laboriosos. En esta tesis se implement\u00f3 el modelo de aprendizaje profundo DeeProtGO con el objetivo de predecir anotaciones de Gene Ontology (GO) en prote\u00ednas derivadas de la secuenciaci\u00f3n del par\u00e1sito Dioctophyme renale. El modelo fue entrenado inicialmente con prote\u00ednas de organismos de distintos taxones y posteriormente reentrenado con subconjuntos de prote\u00ednas de nematodos filogen\u00e9ticamente cercanos, evaluando su impacto en la capacidad predictiva. Se analiz\u00f3 adem\u00e1s la relaci\u00f3n entre la longitud proteica y la presencia de anotaciones, observ\u00e1ndose que las prote\u00ednas m\u00e1s cortas presentaban una menor proporci\u00f3n de anotaciones.<\/p>\n<p>Sin embargo, la precisi\u00f3n de las predicciones en procesos biol\u00f3gicos no disminuy\u00f3 de forma significativa en prote\u00ednas de menos de 240 amino\u00e1cidos. El mejor rendimiento, con un Fmax de 0.23 para funciones moleculares, se obtuvo al incluir prote\u00ednas de D. renale en el entrenamiento, aunque con un umbral alto (t=0.98), lo que sugiere un modelo conservador y con limitada generalizaci\u00f3n. Finalmente, se explor\u00f3 la distribuci\u00f3n espacial de secuencias ort\u00f3logas en muestras de Brugia malayi mediante Spatial Transcriptomics, lo que permiti\u00f3 mapear la localizaci\u00f3n anat\u00f3mica de prote\u00ednas predichas, ampliando el marco funcional y espacial de estas anotaciones.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>El Viernes 10\/04 se realiz\u00f3 la Defensa de Tesis de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":43,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1618","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categoria"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Defensa de Tesis - \u00c1lvaro L\u00f3pez Malizia \u2013 10\/04\/2026 \u2013 10 hs. - Maestr\u00eda en Data Mining<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/datamininguba.com.ar\/datamining\/2026\/03\/26\/defensa-de-tesis-alvaro-lopez-malizia-10-04-2026-10-hs\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Defensa de Tesis - \u00c1lvaro L\u00f3pez Malizia \u2013 10\/04\/2026 \u2013 10 hs. - Maestr\u00eda en Data Mining\" \/>\n<meta property=\"og:description\" content=\"El Viernes 10\/04 se realiz\u00f3 la Defensa de Tesis de [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/datamininguba.com.ar\/datamining\/2026\/03\/26\/defensa-de-tesis-alvaro-lopez-malizia-10-04-2026-10-hs\/\" \/>\n<meta property=\"og:site_name\" content=\"Maestr\u00eda en Data Mining\" \/>\n<meta property=\"article:published_time\" content=\"2026-03-26T06:27:07+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-10T14:43:10+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/datamininguba.com.ar\/datamining\/wp-content\/uploads\/2022\/07\/DSC_6018.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1500\" \/>\n\t<meta property=\"og:image:height\" content=\"1001\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/datamininguba.com.ar\\\/datamining\\\/2026\\\/03\\\/26\\\/defensa-de-tesis-alvaro-lopez-malizia-10-04-2026-10-hs\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/datamininguba.com.ar\\\/datamining\\\/2026\\\/03\\\/26\\\/defensa-de-tesis-alvaro-lopez-malizia-10-04-2026-10-hs\\\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\\\/\\\/datamininguba.com.ar\\\/datamining\\\/#\\\/schema\\\/person\\\/2da5fff668c3c60dfcc2385cfd534a17\"},\"headline\":\"Defensa de Tesis &#8211; 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